Houston's Lance McCullers Jr. and Pittsburgh's Paul Skenes put on a pitching duel won by the Astros, Ryan Gusto (3-2, 4.62 ERA) and Mike Burrows (0-1, 8.64 ERA) square off in the second of a three-game series.

Pregame analysis and predictions of the Houston Astros vs. Pittsburgh Pirates MLB game to be played on June 4, 2025 on ESPN.

The Pirates dropped 2 of 3 games at the San Diego Padres, losing 6-4 as +133 underdogs in the Sunday finale with the Over (8.5) hitting. Pittsburgh held an 83.9% win probability, according to ESPN Analytics, leading 4-1 with 1 out in the bottom of the sixth inning Sunday -- but was outscored 5-0 the rest of the way.