George Kirby is slated to take the mound for Seattle against Lance McCullers for Houston.The Astros are hoping to bounce back from an 8-4 loss and a dropped series against the Tampa Bay Rays when McCullers takes the mound today.

The Mariners were unable to hold an early lead as the Astros got to the former All-Star pitcher in his first game back from a shoulder injury.

Mariners Make Unfortunate Julio Rodriguez Announcement Before Astros Game first appeared on Athlon Sports on May 22, 2025

Seattle’s George Kirby didn’t get the results he wanted in his season debut against the Houston Astros but was still encouraged in his return to the mound after a lengthy absence.

George Kirby’s return to the mound ended in a loss and Julio Rodríguez was scratched from the lineup as the Mariners were thumped by the Astros.

Preview the May 22 matchup between the Seattle Mariners and Houston Astros with odds over/under, game spread, betting lines and more.

The series opener against the host Houston Astros on Thursday resulted in a loss for the Mariners as a team, but the Seattle rotation took a step forward.

The Astros have sort of limped along in the muddy middle of the American League standings. As recently as May 14, they were a game behind the Mariners in the AL West, but they’re now 3.5 games back after going 3-4 since that date.

Preview the May 22 matchup between the Seattle Mariners and Houston Astros with recent trends, how to watch, livestream info, and more.

The long-awaited season debut of Mariners' All-Star starting pitcher George Kirby was spoiled by the Astros in a blowout.

Find out how to watch the Houston Astros vs. Seattle Mariners series, with TV channel info, live streaming options, game times, probable starting

The Seattle Mariners are about to finish up their 10-game road trip with four games in Houston against the Astros, and Houston is dealing with another big injury to its starting rotation.