Herbert injured his right leg in the third quarter of Week 2’s 26-3 win against the Carolina Panthers trying to escape the pocket. He walked off the field but returned to the game. Chargers coach Jim Harbaugh said X-rays came back negative. He was a limited participant on Thursday.

The 49ers made the surprising decision to sit their star running back for Monday night's game against the New York Jets, saying McCaffrey's Achilles injury was still bothering him too much to risk it. That would seem to indicate his Week 2 status against the Minnesota Vikings is also very much in doubt.