imageimageThe GndRX system in Legionella pneumophila is a predicted toxin-antitoxin module that causes death during DNA stress. GndRX has non-canonical functionality and appears to be the consequence ...

imageimageIn mouse spermatocytes, the X and Y chromosomes undergo rapid non-homologous synapsis and desynapsis during early pachynema. This study reveals that X-Y desynapsis initiated by the atypical ...

RNA interference (RNAi) is widely used in life science research and is critical for diverse biological processes, such as germline development and antiviral defense. In the germline of Caenorhabditis ...

imageimageSTING inhibits LINE-1 retrotransposition to maintain genomic stability in an IFN-independent manner. STING interacts with LINE-1 ORF1p, sorting ORF1p to lysosomes for degradation. STING ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The bacterial cell wall is primarily composed ...

Abstract Essentiality studies have traditionally focused on coding regions, often overlooking other small genetic regulatory elements. To address this, we combined transposon libraries containing ...

imageimageThe tubulin/FtsZ superfamily of cytoskeletal proteins may have originated in Asgard archaea. This study reveals different filament morphologies membrane tethering mechanisms for the dual ...

Symbiotic bacteria in long-term host associations frequently undergo extreme genome reduction. While they retain genes beneficial to the host, their repertoire of transcription factors is severely ...

Dynamic reorganization of synaptic vesicles, synapsins, and actin is tightly associated with synaptic activity, but the molecular details of their interactions are not fully understood. This study ...