The Blue Jays revealed Guerrero's final status ahead of Friday's bout with the Boston Red Sox, via their social media. The slugger will sit out, and backup Ernie Clement will replace him at first base. Manager John Schneider mentioned that Guerrero's X-rays were negative earlier in the day, via MLB Network radio.

In the fourth, Blue Jays starter Kevin Gausman hit Jose Ramirez in the forearm with a pitch. Ramirez, like Guerrero, stayed in the game to run but was later taken out. Nolan Jones has entered in his place in the lineup, with Lane Thomas moving to center, Angel Martinez moving to second base and Daniel Schneemann shifting to third.