The elaboration of an efficient immune response against pathogens involves complex intracellular antigen-processing events. Endogenous antigens such as viral proteins synthesized by infected host ...
DCs loaded with tumor antigens have been shown to inhibit tumor growth in several mouse models. 6,7 Methods used to load tumor antigen in these studies include pulsing DCs with defined peptide ...
To better understand the generation of MHC class l-associated peptides, we used a model antigenic protein whose proteasomemediated degradation is rapidly and reversibly controlled by Shield-1, a ...
EMERYVILLE, Calif., Feb. 27, 2019 (GLOBE NEWSWIRE) -- Gritstone Oncology, Inc. (Nasdaq:GRTS), a clinical-stage biotechnology company developing the next generation of cancer immunotherapies to fight ...
The major histocompatibility complex (MHC) is a group of genes that encode proteins on the cell surface that have an important role in immune response. Their main role is in antigen presentation where ...
This is a preview. Log in through your library . Abstract Many persistent viruses have evolved the ability to subvert MHC class I antigen presentation. Indeed, human cytomegalovirus (HCMV) encodes at ...
Background: We have shown that the high prevalence of HLA-A2 in Scandinavia is associated to poor prognosis in advanced (stage III-IV) serous adenocarcinoma of the ovary. Our objective was to analyse ...
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