Polyploid genomes, formed through repeated whole-genome duplication and hybridization, underpin the evolution of many important crops, yet their internal structure often remains unresolved when ...

Humanized mouse models are essential for investigating human gene function; however, the complete replacement of mouse genes ...

Understanding human gene function in living organisms has long been hampered by fundamental differences between species.

Researchers at The University of Tokyo developed TECHNO, a two-step genome editing strategy that replaces entire mouse loci with human genomic DNA. The method integrates fragments over 200 kbp.

Production of recombinant therapeutic proteins in mammalian cells represents a significant segment of the pharmaceutical market, and therefore striving for increased productivity of these lines ...