Researchers have developed the first mouse model for a mitochondrial tRNALeu mutation, showing that the associated metabolic disorder results from faulty RNA processing. Studying the role of ...
A study published in Nature Communications revealed a new antisense oligonucleotide (ASO) therapy applicable to the W1282X mutation of the cystic fibrosis transmembrane conductance regulator gene ...
New Computational Model Matches Drugs to Protein Synthesis Disruptors in Hereditary Diseases, Cancer
Genetic diseases that result from truncated proteins can be targeted by so-called nonsense suppression therapies—drugs that prevent protein translation from terminating prematurely. A new ...
tRNAs have a distinct cloverleaf secondary structure and an L-shaped tertiary structure. The cloverleaf structure is formed by the folding of the single-stranded tRNA molecule, which is typically ...
A team of researchers has uncovered a previously unrecognized role of mitochondrial protein synthesis in the maintenance of intracellular iron distribution. Disruption of this process was found to ...
A research team led by Prof. XU Zhiheng from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences has identified Tapt1, together with its partner Suco, as important ...
Tsukuba, Japan—Studying the role of mitochondria—the specialized structures within cells responsible for energy production—in metabolic diseases has been difficult because of a lack of animal models ...
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