One of the hallmarks of many DNA polymerases is that they proofread as they copy DNA, ensuring high-fidelity duplicates of an organism’s genome. This error-checking ability is missing from enzymes ...
The inhibition of HIV-1’s replicative machinery remains a cornerstone in the battle against AIDS. Central to this approach are inhibitors targeting reverse transcriptase (RT) and integrase. Reverse ...
Combined Intraperitoneal and Intravenous Chemotherapy for Women With Optimally Debulked Ovarian Cancer: Results From an Intergroup Phase II Trial Purpose: To evaluate in vivo whether the expression of ...
Correction 6/18/21: The original version of this article stated that polymerase theta was the first mammalian polymerase with the ability to transcribe RNA into DNA. In fact, other polymerases have ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 85, No. 10 (May 15, 1988), pp. 3372-3376 (5 pages) Reverse transcriptase of the avian sarcoma and leukosis ...
Regimen for treatment-experienced patients Use treatment history, past and current resistance profiles, and identifiable causes of treatment failure to design new regimen with at least 2 (preferably 3 ...
Background. Plasma concentrations of tenofovir increase when the drug is coadministered with some ritonavirboosted protease inhibitors (PI/r). We hypothesized that tenofovir disoproxil fumarate ...
CAMBRIDGE, Mass.--(BUSINESS WIRE)--ROME Therapeutics, a biotechnology company harnessing the power of the dark genome for drug development, today announced a new publication in The Proceedings of the ...
Cardiomyopathy with Mitochondrial Damage Associated with Nucleoside Reverse-Transcriptase Inhibitors
In July 2000, a 58-year-old man infected with the human immunodeficiency virus (HIV) began treatment with highly active antiretroviral therapy, which initially consisted of zidovudine, lamivudine, and ...
† Drugs combined with NRTIs or NRTIs/NNRTIs are not listed. NNRTIs: Non-nucleoside reverse-transcriptase inhibitors; NRTIs: Nucleos(t)ide analog reverse-transcriptase inhibitors. Drug-resistance amino ...
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