Omeros Announces Publication of Study Showing that Inhibition of MASP-2, the Key Enzyme of the Complement System’s Lectin Pathway, Protects Against Renal Injury Caused by Proteinuria ...

Omeros’ OMS721 is a human monoclonal antibody that inhibits MASP-2, which is the effector enzyme of the lectin pathway of the complement system.

The Mannan-binding lectin serine protease (MASP) protein family is critical for the complement pathway in the immune system.

After a slow start, the race is on to inhibit key proteins and pathways within the complement system -- a biological cascade that is central to the innate immune system and many different diseases ...

The "dextran" in superparamagnetic dextran iron oxide nanoworms is a sugar that is recognized by the lectin pathway, activating the complement system and resulting in the immune system attacking ...

OMS721 selectively inhibits MASP-2, blocking the lectin pathway of the complement system while leaving intact the classical pathway, or the acquired immune response to infection.

The complement system can be activated through the following three distinct pathways: the classical, lectin and alternative.

OMS906 is an investigational human monoclonal antibody targeting mannan-binding lectin-associated serine protease-3 (MASP-3), the key activator of the complement system’s alternative pathway.

Mannose-binding lectin and the lectin complement pathway evolved well before antibodies and are often considered to be proto-antibodies.

Omeros Announces Publication of Study Showing that Inhibition of MASP-2, the Key Enzyme of the Complement System’s Lectin Pathway, Protects Against Renal Injury Caused by Proteinuria ...