Recent advances in next-generation sequencing (NGS) make it possible to directly sequence genomes and exomes of individuals with Mendelian diseases and screen sequence data for causal variants. With ...

The template method design pattern allows you to define the skeleton of an algorithm in a base class and defer the details to subclasses Design patterns are proven solutions to recurring problems and ...

Practical .NET Move Beyond Factory Methods with the Builder Pattern in C#/Visual Basic When your objects get sufficiently complicated to create, it's time to simplify your life by moving to the ...

In my two immediately previous posts, I looked at reducing the number of parameters required for a constructor or method invocation via custom types and parameter objects. In this post, I look at use ...