An illustration provided by NCSU shows the critical decoding structure produced when modified nucleosides enable tRNA to decode by “wobble” recognition. Only the decoding region of a 50,000+ atom ...

For disorders driven by a known genetic component, research understandably focuses on developing a drug targeting that genetic signature. When that works, the outcome benefits patients but the end ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, No. 27 (Jul. 3, 2007), pp. 11268-11273 (6 pages) Pyrrolysine (Pyl), the 22nd natural amino acid and ...

A tRNA that recognizes the codon for tryptophan and delivers this amino acid to the ribosome. (Note 5) 2′-O-methylcytidine (Cm): A modified nucleoside in which the 2′-OH group of the ribose in ...

Aminoacyl-tRNA synthetases (aaRSs) are ancient and evolutionary conserved enzymes catalyzing the formation of aminoacyl-tRNAs, that are used as substrates for ribosomal protein biosynthesis. In ...

In eukaryotes, there are four rRNAs associated with ribosomes; these are the 18S, 5.8S, 28s, and 5S rRNAs. Production of the first three occurs within the nucleolus, whereas 5S rRNA production occurs ...

Pyrrolysine is an important component of methyltransferase enzymes, which the archaea use to metabolize methylamine in the environment. “The need for that metabolism and availability of the machinery ...

With a move into Lilly Gateway Labs in Boston’s Seaport District, privately held Tevard Biosciences Inc. is ramping up development of its transfer RNA (tRNA)-based therapies to cure everything from ...

Birds have been shaped by evolution in many ways that have made them distinct from their vertebrate cousins. Over millions of years of evolution, our feathered friends have taken to the skies, ...

HC Bioscience is shutting down after conducting preclinical models for a transfer RNA (tRNA) asset designed to treat hemophilia A. The Cambridge, Massachusetts-based biotech is closing “following ...