Closures on I-10 in Phoenix are coming this weekend. What to avoid

Here are the detours to take to prevent destination delays because of closures on Interstate 10 near downtown.

Organic growth breathes new life into Calgary’s Marda Loop

The downtown neighbourhood has experienced significant change in the last decade without a specific redevelopment plan in ...

Houston Texans at Pittsburgh Steelers best prop bets for AFC Wild Card

The Houston Texans and Pittsburgh Steelers play in the AFC Wild Card Monday at 8:15 p.m. ET. Here are the best prop bets for the matchup.

Ravens Kicker Tyler Loop Getting Support From the Most Unlikely Places

Ravens kicker Tyler Loop received unexpected support after his missed field goal, including prayers and donations from ...

Variawa’s incredible comeback snatches stage in Dakar Rally and Benavides rides to another win

Saood Variawa has snatched stage eight from South African compatriot Henk Lategan by three seconds after an impressive ...

Only in Alaska. Welcome to the 'totem pole capital of the world.'

KETCHIKAN, Alaska – An arched sign stretching between two city blocks welcomes travelers to “ Alaska’s first city ” and the “ ...

Mike Tomlin and the Steelers look to end a long run of playoff futility against the streaking Texans

Mike Tomlin and the AFC North champion Pittsburgh Steelers host streaking Houston in the first round of the NFL playoffs, ...

Maricopa County has a new plan to fund its animal shelters. Here's how

County officials say the nonprofit Friends of Animal Care and Control will help to pay for nonmandated activities supported ...
eLife

Replication stress-inducing ELF3 upregulation promotes BRCA1-deficient breast tumorigenesis in luminal progenitors

ELF3 axis enables luminal progenitor transformation in BRCA1-deficient breast cancer by reducing genomic instability and promoting progenitor identity.