eLife

A proteome-wide biochemical screen defines binding determinants of the core autophagy protein LC3B

Human MAP1LC3B (LC3B) binds proteins involved in autophagy and other cellular processes using a degenerate four-residue short linear motif known as the LC3-interacting region (LIR). Biochemical and ...
The BMJ

Adherence to legislation and recommendations to publicly post protocols and results of post-authorisation studies registered with European Medicines Agency: cross sectional study

Objective To assess whether post-authorisation studies registered with the European Medicines Agency (EMA) adhere to legislation and recommendations to publicly post study protocols and results.
eLife

TAD boundary architecture and gene activity are uncoupled

A proposed function of TADs is to contribute to gene regulation by promoting chromatin interactions within a TAD and by suppressing interactions between TADs. Here, we directly probe the ...
The New York Times

Climate and Environment

Greenpeace has said the verdict could bankrupt it. The lawsuit was over the group’s role in protests against the Dakota Access Pipeline. By Karen Zraick Simultaneous emergencies in different parts of ...