STAT

I tried to design a clinical trial for a supplement. 5 things got in the way

When Elise Felicione tried to design a clinical trial for a supplement, 5 things got in the way. It’s a lesson for the ...
News-Medical.Net

New global guidelines improve reporting of pediatric randomized controlled trials

Researchers at The Hospital for Sick Children (SickKids), working with international collaborators and youth and family ...
Macworld

Not convinced of macOS Tahoe’s terrible design? Here’s the best (worst) example

First, it was Liquid Glass. Then it was the icons. And then it was the icons again (though it’s a different set of icons). Now, there’s something else about macOS Tahoe’s redesign that annoys the heck ...
IPM

Randomized control trial shows drinking water promotion can prevent overweight and reduce sugar-sweetened beverage intake in schoolchildren

A new study in the American Journal of Preventive Medicine reports findings from a randomized controlled trial—the gold standard study design in health research—showing that promoting drinking water ...
IEEE

Randomized Customer-Sensitivity-Aware Control of Thermostatic Loads for Better Integration of Intermittent Renewables

Abstract: Increased electric grid penetration of intermittent renewable energy sources has reduced the controllability of the generation side and created a need for more coordination between ...
FierceBiotech

FDA steers cancer CAR-T developers toward randomized superiority trials in policy shift

The FDA is raising the bar for approval of CAR T-cell therapies in oncology. Under plans outlined by the FDA’s biologics chief Vinay Prasad, M.D., the agency will require developers of many CAR-Ts to ...
IEEE

Safety-Critical Randomized Event-Triggered Learning of Gaussian Process With Applications to Data-Driven Predictive Control

Abstract: Safety and data efficiency are important concerns in data-driven control, especially for nonlinear systems with unknown dynamics and subject to disturbances. In this work, we consider a ...
ahajournals.org

Abstract 4363704: YOSEMITE Rationale and Design: Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Zodasiran Efficacy and Safety in Adolescents and Adults with ...

Methods: YOSEMITE is a phase 3, randomized, double-blind, placebo-controlled trial. Key inclusion criteria are genetically confirmed HoFH or a clinical diagnosis (total cholesterol >500 mg/dL OR ...
The New England Journal of Medicine

A Pragmatic Trial of Glucocorticoids for Community-Acquired Pneumonia

Adjunctive glucocorticoids may reduce mortality among patients with severe community-acquired pneumonia (CAP) in well-resourced settings. Whether these drugs are beneficial in low-resource settings ...
SciELO

Schizophrenia TreAtment with electRic Transcranial Stimulation (STARTS): design, rationale and objectives of a randomized, double-blinded, sham-controlled trial

Introduction Schizophrenia is a severe mental disorder. While some antipsychotic medications have demonstrated efficacy in treating positive symptoms, there is no widely recognized treatment for ...
Frontiers

Safety and efficacy of esketamine combined with propofol or ciprofol sedation for electroconvulsive therapy in patients with major depressive disorder: protocol for a ...

Electroconvulsive therapy (ECT) is one of the main strategies for major depressive disorder (MDD). Recently, the use of esketamine in the treatment of depression due to the rapid antidepressant ...
The Lancet

Bedaquiline, delamanid, linezolid, and clofazimine for rifampicin-resistant and fluoroquinolone-resistant tuberculosis (endTB-Q): an open-label, multicentre, stratified, non ...

aeTranslational Research on HIV and Endemic and Emerging Infectious Diseases, Montpellier Université de Montpellier, Institut de Recherche pour le Développement, INSERM, Montpellier, France ...